Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. To bridge the evidence gap in women’s health, look at the real world As the availability of clinical trial data continues to lag behind, other forms of evidence generation leveraging real-world data and citizen science need to be considered to improve women’s health. AI-based clinician decision support system for diagnosis of inherited retinal diseases: a multicenter, randomized trial Retina4IRD, an AI-based clinician decision support system, enhances inherited retinal disease diagnosis through multimodal imaging and clinical data integration, achieving 88.5% accuracy in a randomized clinical trial. Huixun Jia Bo Qian Xiaodong Sun Article 24 Jul 2026 AI-based clinician decision support system for diagnosis of inherited retinal diseases: a multicenter, randomized trial Retina4IRD, an AI-based clinician decision support system, enhances inherited retinal disease diagnosis through multimodal imaging and clinical data integration, achieving 88.5% accuracy in a randomized clinical trial. Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making. Arsela Prelaj Vanja Miskovic On behalf of the I3LUNG Consortium Article Open Access 13 Sept 2026 Clinical usability of an explainable AI decision support tool and evaluation of multimodal models in NSCLC In a large international real-world study of non-small cell lung cancer, a multimodal explainable AI model outperformed established biomarkers for immunotherapy outcome prediction and improved physician decision-making. On behalf of the I3LUNG Consortium Inhaled siRNA therapy targeting RAGE for pulmonary inflammation: a first-in-human randomized trial Following preclinical development, a randomized first-in-human trial showed that treatment with an inhaled, lung-epithelium-targeted siRNA directed against the receptor for advanced glycation end-products (RAGE) was safe and well tolerated and reduced RAGE levels in serum and bronchoalveolar lavage fluid. Mark O’Carroll David Kasahara on behalf of the RAGE study consortium Article Open Access 09 Sept 2026 Inhaled siRNA therapy targeting RAGE for pulmonary inflammation: a first-in-human randomized trial Following preclinical development, a randomized first-in-human trial showed that treatment with an inhaled, lung-epithelium-targeted siRNA directed against the receptor for advanced glycation end-products (RAGE) was safe and well tolerated and reduced RAGE levels in serum and bronchoalveolar lavage fluid. on behalf of the RAGE study consortium A multimodal murmuration for immunotherapy A study shows that integrating numerous multimodal, patient-level biomarkers enhances the prediction of cancer immunotherapy response, but generalizability is still a challenge. Raquel Perez-Lopez Mireia Crispin-Ortuzar News & Views 13 Sept 2026 A multimodal murmuration for immunotherapy A study shows that integrating numerous multimodal, patient-level biomarkers enhances the prediction of cancer immunotherapy response, but generalizability is still a challenge. Raquel Perez-Lopez Mireia Crispin-Ortuzar To bridge the evidence gap in women’s health, look at the real world Editorial 09 Sept 2026 To bridge the evidence gap in women’s health, look at the real world AI decision support is scaling-up fast — can the evidence keep up? Paul Webster News 13 Aug 2026 AI decision support is scaling-up fast — can the evidence keep up? Can traditional medicines go mainstream? Ben Deighton News Feature 21 Aug 2026 Can traditional medicines go mainstream? How to build an AI-driven digital organism Le Song Eran Segal Eric Xing Perspective 13 Aug 2026 How to build an AI-driven digital organism Induced pluripotent stem cells from discovery to translation Jaecheol Lee Todd Herron Joseph C. Wu Review Article 27 Aug 2026 Induced pluripotent stem cells from discovery to translation County, district and community-level measles transmission in the United States in 2013−2025 Siyu Chen Ana I. Bento Article 18 Aug 2026 County, district and community-level measles transmission in the United States in 2013−2025 Nature Medicine Commission: Quality Health Information The Nature Medicine Commission on Quality Health Information for All aims to promote equitable access to reliable health information from trusted sources and to re‑envision health communication for the digital era. The Commission defines quality health information as information that is “scientifically sound, accessible, clear, and understandable, and that supports policy decision‑making. Nature Medicine Commission: Quality Health Information The Nature Medicine Commission on Quality Health Information for All aims to promote equitable access to reliable health information from trusted sources and to re‑envision health communication for the digital era. The Commission defines quality health information as information that is “scientifically sound, accessible, clear, and understandable, and that supports policy decision‑making. Nature Medicine Commission: dialysis policy in LMICs This Nature Medicine Commission aims to address the current dialysis policy challenges in Thailand and generate lessons for the global kidney community. This Collection brings together the main Commission Report along with linked research articles, reviews and commentaries published across the Nature Portfolio. Nature Medicine Commission: dialysis policy in LMICs This Nature Medicine Commission aims to address the current dialysis policy challenges in Thailand and generate lessons for the global kidney community. This Collection brings together the main Commission Report along with linked research articles, reviews and commentaries published across the Nature Portfolio. Focus on Infectious Diseases Nature Medicine presents a special Focus that highlights challenges and successes in global infectious disease control, including a variety of reviews, news, opinion and original research articles. Focus on Infectious Diseases Nature Medicine presents a special Focus that highlights challenges and successes in global infectious disease control, including a variety of reviews, news, opinion and original research articles. The 1st Nature Flagship Conference - Precision Medicine Join Deputy Editor Liam Messin at the first Nature flagship conference, Reframing Precision Medicine: Innovation to Implementation, from 13–15 October 2026 at the Royal Institution, London The 1st Nature Flagship Conference - Precision Medicine Join Deputy Editor Liam Messin at the first Nature flagship conference, Reframing Precision Medicine: Innovation to Implementation, from 13–15 October 2026 at the Royal Institution, London Latest Research articles Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma Results of this study show in experimental models and data from patient cohorts that the antiseizure medication levetiracetam is associated with longer survival and reduced tumor growth in diffuse midline glioma, but not hemispheric high-grade glioma, by selectively dampening GABAergic synaptic signaling, independently of its canonical SV2A-mediated primary antiseizure mechanism. Tara Barron Richard Drexler Michelle Monje Article Open Access 17 Sept 2026 Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma Results of this study show in experimental models and data from patient cohorts that the antiseizure medication levetiracetam is associated with longer survival and reduced tumor growth in diffuse midline glioma, but not hemispheric high-grade glioma, by selectively dampening GABAergic synaptic signaling, independently of its canonical SV2A-mediated primary antiseizure mechanism. Richard Drexler EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses. Devin A. King Shrishti Saxena Tanuja Chitnis Article Open Access 16 Sept 2026 EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS relapses. Shrishti Saxena Liquid biopsy for early detection of pancreatic ductal adenocarcinoma In a prospective study involving 1,785 individuals from four countries, the PANXEON exosome-based biomarker, combined with carbohydrate antigen 19-9 levels, achieves high sensitivity for the detection of early-stage pancreatic cancer. Caiming Xu Alessandro Mannucci Ajay Goel Article 16 Sept 2026 Liquid biopsy for early detection of pancreatic ductal adenocarcinoma In a prospective study involving 1,785 individuals from four countries, the PANXEON exosome-based biomarker, combined with carbohydrate antigen 19-9 levels, achieves high sensitivity for the detection of early-stage pancreatic cancer. Alessandro Mannucci Factor IX Padua AAV gene therapy in adolescents with hemophilia B: a phase 1 trial In this single-arm phase 1 trial, an AAV gene therapy carrying the Padua variant of factor IX was well tolerated in 11 adolescents with hemophilia B and led to reductions in annualized bleeding rate. Feng Xue Ai Zhang Lei Zhang Article 16 Sept 2026 Factor IX Padua AAV gene therapy in adolescents with hemophilia B: a phase 1 trial In this single-arm phase 1 trial, an AAV gene therapy carrying the Padua variant of factor IX was well tolerated in 11 adolescents with hemophilia B and led to reductions in annualized bleeding rate. Sex-specific biological aging clocks across organs and omics Sex-specific biological aging clocks across multiple organs and molecular systems show that female and male aging patterns can differ in organ-specific, disease-relevant ways. Zhiyuan Song Derek Feng Junhao Wen Article Open Access 16 Sept 2026 Sex-specific biological aging clocks across organs and omics Sex-specific biological aging clocks across multiple organs and molecular systems show that female and male aging patterns can differ in organ-specific, disease-relevant ways. On-premise medical AI agents for reliable clinical decision-making An autonomous clinical AI agent enhances decision-making through on-premise deployment and reliability metrics, achieving high diagnostic accuracy and selective autonomy. Li Zhang Georg Wölflein Jakob Nikolas Kather Article Open Access 15 Sept 2026 On-premise medical AI agents for reliable clinical decision-making An autonomous clinical AI agent enhances decision-making through on-premise deployment and reliability metrics, achieving high diagnostic accuracy and selective autonomy. Jakob Nikolas Kather Latest Reviews & Analysis Beyond the breakthrough for RAS-driven cancers Two early clinical studies of selective KRAS G12D inhibitors show encouraging activity in advanced cancers with G12D mutations, signaling a transformative change in the treatment landscape for RAS-driven cancers with potential applications across tumor types and stages of disease. Rich C. King Erica S. Tsang Jennifer J. Knox News & Views 15 Sept 2026 De novo mutations bridge parental reproductive factors and offspring health Whole-genome sequencing of 7,851 parent–offspring families enabled the identification of parent-of-origin and post-zygotic de novo mutations that were associated with distinct procedures of assisted reproductive technology (ART), independently of parental age at conception. Increased paternal mutational burden statistically mediates the effects of advanced parental age and ART on gestational duration and other birth outcomes. Research Briefing 14 Sept 2026 A multimodal murmuration for immunotherapy A study shows that integrating numerous multimodal, patient-level biomarkers enhances the prediction of cancer immunotherapy response, but generalizability is still a challenge. Raquel Perez-Lopez Mireia Crispin-Ortuzar News & Views 13 Sept 2026 Our Future Health and the next generation of population medicine An early assessment of the UK’s Our Future Health project shows how national-scale cohorts may reshape population medicine by accelerating discovery and clinical recruitment, provided that selection and phenotyping biases are carefully measured and managed. Zhonghan Sun Yan Zheng News & Views 10 Sept 2026 Gene alteration in human brain suggests genetic and epigenetic roots of major depression A large, multimodal molecular characterization of the adult human hippocampus provides evidence for sustained neurogenesis and identifies a stalled neurogenic process in major depressive disorder (MDD). Cell- and circuit-specific genetic, epigenetic, stress, immune, metabolic and synaptic mechanisms are identified that underlie impaired hippocampal plasticity, providing a framework for disease subtyping and therapeutic development. Research Briefing 03 Sept 2026 Beyond the breakthrough for RAS-driven cancers Two early clinical studies of selective KRAS G12D inhibitors show encouraging activity in advanced cancers with G12D mutations, signaling a transformative change in the treatment landscape for RAS-driven cancers with potential applications across tumor types and stages of disease. Rich C. King Erica S. Tsang Jennifer J. Knox News & Views 15 Sept 2026 Beyond the breakthrough for RAS-driven cancers Two early clinical studies of selective KRAS G12D inhibitors show encouraging activity in advanced cancers with G12D mutations, signaling a transformative change in the treatment landscape for RAS-driven cancers with potential applications across tumor types and stages of disease. Jennifer J. Knox De novo mutations bridge parental reproductive factors and offspring health Whole-genome sequencing of 7,851 parent–offspring families enabled the identification of parent-of-origin and post-zygotic de novo mutations that were associated with distinct procedures of assisted reproductive technology (ART), independently of parental age at conception. Increased paternal mutational burden statistically mediates the effects of advanced parental age and ART on gestational duration and other birth outcomes. Research Briefing 14 Sept 2026 De novo mutations bridge parental reproductive factors and offspring health Whole-genome sequencing of 7,851 parent–offspring families enabled the identification of parent-of-origin and post-zygotic de novo mutations that were associated with distinct procedures of assisted reproductive technology (ART), independently of parental age at conception. Increased paternal mutational burden statistically mediates the effects of advanced parental age and ART on gestational duration and other birth outcomes. A multimodal murmuration for immunotherapy A study shows that integrating numerous multimodal, patient-level biomarkers enhances the prediction of cancer immunotherapy response, but generalizability is still a challenge. Raquel Perez-Lopez Mireia Crispin-Ortuzar News & Views 13 Sept 2026

A multimodal murmuration for immunotherapy A study shows that integrating numerous multimodal, patient-level biomarkers enhances the prediction of cancer immunotherapy response, but generalizability is still a challenge. Raquel Perez-Lopez Mireia Crispin-Ortuzar Our Future Health and the next generation of population medicine An early assessment of the UK’s Our Future Health project shows how national-scale cohorts may reshape population medicine by accelerating discovery and clinical recruitment, provided that selection and phenotyping biases are carefully measured and managed. Zhonghan Sun Yan Zheng News & Views 10 Sept 2026 Our Future Health and the next generation of population medicine An early assessment of the UK’s Our Future Health project shows how national-scale cohorts may reshape population medicine by accelerating discovery and clinical recruitment, provided that selection and phenotyping biases are carefully measured and managed. Gene alteration in human brain suggests genetic and epigenetic roots of major depression A large, multimodal molecular characterization of the adult human hippocampus provides evidence for sustained neurogenesis and identifies a stalled neurogenic process in major depressive disorder (MDD). Cell- and circuit-specific genetic, epigenetic, stress, immune, metabolic and synaptic mechanisms are identified that underlie impaired hippocampal plasticity, providing a framework for disease subtyping and therapeutic development. Research Briefing 03 Sept 2026 Gene alteration in human brain suggests genetic and epigenetic roots of major depression A large, multimodal molecular characterization of the adult human hippocampus provides evidence for sustained neurogenesis and identifies a stalled neurogenic process in major depressive disorder (MDD). Cell- and circuit-specific genetic, epigenetic, stress, immune, metabolic and synaptic mechanisms are identified that underlie impaired hippocampal plasticity, providing a framework for disease subtyping and therapeutic development. Isthmin 2 could determine the early origins of preeclampsia and fetal growth restriction Research Briefing 02 Sept 2026 Altered oligodendrocyte function promotes cognitive decline in aging Research Briefing 01 Sept 2026 Scaling rapid whole-genome sequencing for critical pediatric care in the Middle East Research Briefing 27 Aug 2026 Induced pluripotent stem cells from discovery to translation Jaecheol Lee Todd Herron Joseph C. Wu Review Article 27 Aug 2026 Isthmin 2 could determine the early origins of preeclampsia and fetal growth restriction Research Briefing 02 Sept 2026 Isthmin 2 could determine the early origins of preeclampsia and fetal growth restriction Altered oligodendrocyte function promotes cognitive decline in aging Research Briefing 01 Sept 2026 Altered oligodendrocyte function promotes cognitive decline in aging Scaling rapid whole-genome sequencing for critical pediatric care in the Middle East Research Briefing 27 Aug 2026 Scaling rapid whole-genome sequencing for critical pediatric care in the Middle East Induced pluripotent stem cells from discovery to translation Jaecheol Lee Todd Herron Joseph C. Wu Review Article 27 Aug 2026 Induced pluripotent stem cells from discovery to translation How genes shape personality and experience A genome-wide association study involving over one million people reveals genetic contributions to personality traits, with potential causal effects on physical and mental health and behaviors. Karen O’Leary Research Highlight 18 Sept 2026 How genes shape personality and experience A genome-wide association study involving over one million people reveals genetic contributions to personality traits, with potential causal effects on physical and mental health and behaviors. Rethinking the global health system for a new international order In this Comment, we argue for a global health system that recognizes and supports countries as the primary agents of action, oriented around global public goods and collective action, and served by a leaner set of global and regional institutions. We present a potential vision for the functions and distribution of labor in the system to inform ongoing reform discussions and draw critique, dissent and amendment. Kumanan Rasanathan Keith Cloete John-Arne Røttingen Comment 14 Sept 2026 Rethinking the global health system for a new international order In this Comment, we argue for a global health system that recognizes and supports countries as the primary agents of action, oriented around global public goods and collective action, and served by a leaner set of global and regional institutions. We present a potential vision for the functions and distribution of labor in the system to inform ongoing reform discussions and draw critique, dissent and amendment. Kumanan Rasanathan John-Arne Røttingen Prospective evidence for conversational medical AI is hard, but non-negotiable Trust in clinical artificial intelligence (AI) cannot be benchmarked into existence. It must be earned through rigorous prospective studies in real-world clinical settings, where the hardest lessons often concern the humans and systems around the AI, not the technology itself. Mike Schaekermann Anil Palepu Po-Hsuan Cameron Chen Comment 14 Sept 2026 Prospective evidence for conversational medical AI is hard, but non-negotiable Trust in clinical artificial intelligence (AI) cannot be benchmarked into existence. It must be earned through rigorous prospective studies in real-world clinical settings, where the hardest lessons often concern the humans and systems around the AI, not the technology itself. Mike Schaekermann Po-Hsuan Cameron Chen A global digital navigator of human health for precision medicine The International Consortium of Digital Twins in Healthcare and Medicine was established to advance medical digital twin technology as a new infrastructure for precision health. Kang Zhang Jiahong Dong Guang Ning Comment 11 Sept 2026 A global digital navigator of human health for precision medicine The International Consortium of Digital Twins in Healthcare and Medicine was established to advance medical digital twin technology as a new infrastructure for precision health. The Value Cube: translating clinical benefit into realizable value in global oncology Bibek Aryal Ophira Ginsburg Dario Trapani Correspondence 10 Sept 2026 The Value Cube: translating clinical benefit into realizable value in global oncology Ophira Ginsburg Initial lessons from real-world implementation of an AI-agent eye clinic in China The transition from AI-assisted tools to more integrated, AI-native models of care requires workflow integration, clinician engagement and measurable clinical value. Tao Yan Di Zhang Tien Yin Wong Comment 10 Sept 2026 Initial lessons from real-world implementation of an AI-agent eye clinic in China The transition from AI-assisted tools to more integrated, AI-native models of care requires workflow integration, clinician engagement and measurable clinical value. Trending - Altmetric Liquid biopsy for early detection of pancreatic ductal adenocarcinoma Liquid biopsy for early detection of pancreatic ductal adenocarcinoma On-premise medical AI agents for reliable clinical decision-making On-premise medical AI agents for reliable clinical decision-making EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse Initial lessons from real-world implementation of an AI-agent eye clinic in China Initial lessons from real-world implementation of an AI-agent eye clinic in China Tenure-Track Faculty Position in Computational or Theoretical Neuroscience Seeking a tenure-track Assistant Professor in Computational/Theoretical Neuroscience to advance brain science through innovation and collaboration. Durham, North Carolina Duke University Neurobiology Dept Tenure-Track Faculty Position in Computational or Theoretical Neuroscience Seeking a tenure-track Assistant Professor in Computational/Theoretical Neuroscience to advance brain science through innovation and collaboration. Durham, North Carolina Duke University Neurobiology Dept Faculty Positions in AI for Life Sciences at Westlake University Invites applications for tenure-track or tenured faculty positions at all academic ranks in the field of artificial intelligence for life sciences. Hangzhou, Zhejiang (CN) Westlake University School of Life Science Faculty Positions in AI for Life Sciences at Westlake University Invites applications for tenure-track or tenured faculty positions at all academic ranks in the field of artificial intelligence for life sciences. Hangzhou, Zhejiang (CN) Westlake University School of Life Science Principal Investigator and Postdoctoral Positions at Chinese Institute for Medical Physiology, CIMR Chinese Institute for Medical Physiology at CIMR in Beijing, China, is expanding its recruitment of PIs at all ranks and postdoctoral fellows. Beijing (CN) The Chinese Institutes for Medical Research (CIMR), Beijing Principal Investigator and Postdoctoral Positions at Chinese Institute for Medical Physiology, CIMR Chinese Institute for Medical Physiology at CIMR in Beijing, China, is expanding its recruitment of PIs at all ranks and postdoctoral fellows. The Chinese Institutes for Medical Research (CIMR), Beijing Assistant Professor (Tenure-Track) Faculty Position Tenure track Assistant Professor position in Pharmaceutical Sciences at the University of Michigan Ann Arbor, Michigan University of MI- College of Pharmacy Assistant Professor (Tenure-Track) Faculty Position Tenure track Assistant Professor position in Pharmaceutical Sciences at the University of Michigan Ann Arbor, Michigan University of MI- College of Pharmacy Open Rank General Oncologist The University of New Mexico is seeking a fellowship-trained surgical oncologist to join the Division of Surgical Oncology as an Open Rank faculty ... Albuquerque, New Mexico Sangeetha Prabhakaran MD, FACS, FSSO Open Rank General Oncologist The University of New Mexico is seeking a fellowship-trained surgical oncologist to join the Division of Surgical Oncology as an Open Rank faculty ... Albuquerque, New Mexico Sangeetha Prabhakaran MD, FACS, FSSO Explore articles by subject Guide to authors Editorial policies